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Casein Kinase Related Products (93)
Related Products (93)
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Casein kinase 1δ-IN-22
0 ImagesCat. No.: HY-169701CAS No.: 756849-12-4Casein kinase 1δ-IN-22 (compound 484) is a potent casein kinase 1δ inhibitor. Casein kinase 1δ-IN-22 can be used in the study of neurodegenerative diseases such as Alzheimer's disease.
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Casein Kinase 2
0 ImagesCat. No.: HY-E70625Casein Kinase 2 (CK2) is a serine/threonine protein kinase that is highly conserved among eukaryotes and has roles in many different cellular processes, such as cell survival, cell cycle regulation, cell polarity, stress responses, transcription and translation.
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Casein Kinase II Substrate acetate
0 ImagesCat. No.: HY-P3921APurity: 99.93%Casein Kinase II Substrate acetate is a casein kinase II (CK2) peptide substrate that can be selectively phosphorylated by CK2.
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Lck degrader-1
0 ImagesCat. No.: HY-175280CAS No.: 3095033-62-5Lck degrader-1 is a molecular glue degrader that recruits cereblon to target LCK and CK1α. Lck degrader-1 promotes the formation of the LCK/CRBN-DDB1 ternary complex with an EC50 of 77.1 nM, and induces the degradation of LCK and CK1α. LCK degradation induced by Lck degrader-1 depends on the G415-containing helical G-loop degron, and maintains LCK-degrading activity in cells with the LCK T316I gatekeeper mutation. Lck degrader-1 can be used for research related to T-cell acute lymphoblastic leukemia (T-ALL) and LCK inhibitor resistance.
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CK1δ-IN-6
0 ImagesCat. No.: HY-169719CAS No.: 565167-37-5CK1δ-IN-6 (Compound 303) is a Casein kinase 1δ inhibitor. CK1δ-IN-6 is promising for research of Alzheimer's disease.
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BMS-135-L-Lys TFA
0 ImagesCat. No.: HY-184414ABMS-135-L-Lys TFA is a dual-cation prodrug derived from CK2 inhibitor BMS-135 (HY-181022) through esterification with L-lysine using a secondary alcohol. BMS-135-L-Lys TFA achieves enhanced solubility by maintaining protonation of the ε-amino group of the Lys side chain at intestinal pH. BMS-135-L-Lys TFA is released in situ by intestinal wall esterase from the parent drug, significantly increasing the oral bioavailability of the parent drug and overcoming the non-linear pharmacokinetic problem when the dose of the parent drug is increased. BMS-135-L-Lys TFA can be used in related research on colon cancer and lung cancer.
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p38α MAPK/CK1δ inhibitor-1
0 ImagesCat. No.: HY-171301CAS No.: 1572047-84-7
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Umbralisib hydrochloride (Standard)
0 ImagesCat. No.: HY-12279CRCAS No.: 1532533-78-0Synonyms: TGR-1202 hydrochloride (Standard); RP5264 hydrochloride (Standard)Umbralisib (hydrochloride) (Standard) is the analytical standard of Umbralisib (hydrochloride). This product is intended for research and analytical applications. Umbralisib (TGR-1202) hydrochloride is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC50 of 22.2 nM and 6.0 μM, respectively. Umbralisib hydrochloride exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib hydrochloride can be used for haematological malignancies reseach.
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CK1δ-IN-7
0 ImagesCat. No.: HY-169556CAS No.: 882220-11-3CK1δ-IN-7 (Compound 488) is the inhibitor for casein kinase 1δ (CK1δ).
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TAK-715 (Standard)
0 ImagesCat. No.: HY-10456RCAS No.: 303162-79-0TAK-715 (Standard) is the analytical standard of TAK-715 (HY-10456). This product is intended for research and analytical applications. TAK-715 is an orally active and potent p38 MAPK inhibitor with IC50s of 7.1 nM, 200 nM for p38α and p38β, respectively. TAK-715 inhibits casein kinase I (CK1δ/ε) to regulate activation of Wnt/β-catenin signaling. TAK-715 shows good significant efficacy in a rat arthritis model.
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CZP-IN-1
0 ImagesCat. No.: HY-170782CZP-IN-1 (compound SH-1) is an inhibitor targeting the pathogen Trypanosoma cruzi cruzipain (CZP) and does not inhibit cathepsin L (IC50=28 nM). CZP-IN-1 can be used for the research of Chagas disease.
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CK1δ-IN-8
0 ImagesCat. No.: HY-W840382CAS No.: 438018-70-3CK1δ-IN-8 (Compound 429) is a CK1δ inhibitor that can be used in Alzheimer's disease research.
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AMG-548 dihydrochloride (Standard)
0 ImagesCat. No.: HY-108642BRCAS No.: 2518299-32-4AMG-548 dihydrochloride (Standard) is the analytical standard of AMG-548 (dihydrochloride) (HY-108642B). This product is intended for research and analytical applications. AMG-548 dihydrochloride, an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ. AMG-548 dihydrochloride is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50=3 nM). AMG-548 dihydrochloride inhibits Wnt signaling by directly inhibiting Casein Kinase 1 isoforms δ and ε.
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D4476 (Standard)
0 ImagesCat. No.: HY-10324RCAS No.: 301836-43-1Synonyms: Casein Kinase I Inhibitor (Standard)
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Umbralisib (Standard)
0 ImagesSynonyms: TGR-1202 (Standard); RP5264 (Standard)Umbralisib (Standard) is the analytical standard of Umbralisib. This product is intended for research and analytical applications. Umbralisib (TGR-1202) is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC50 of 22.2 nM and 6.0 μM, respectively. Umbralisib exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib can be used for haematological malignancies reseach.
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CIGB-300
0 ImagesCat. No.: HY-P4056CAS No.: 1072877-99-6Synonyms: P15-TatCIGB-300 (P15-Tat) is an anti-casein kinase 2 (CK2) peptide that exhibits anticancer properties by interfering with the phosphorylation of protein kinase CK2. CIGB-300 induces apoptosis in multiple tumor cell lines and can be used in cancer research.
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Ac-ESMD-CHO
0 ImagesCat. No.: HY-P3234CAS No.: 191338-87-1
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LY294002 hydrochloride (Standard)
0 ImagesLY294002 (hydrochloride) (Standard) is the analytical standard of LY294002 (hydrochloride). This product is intended for research and analytical applications. LY294002 hydrochloride is a potent and broad-spectrum PI3K inhibitor, with IC50 values of 0.5, 0.57, and 0.97 μM for P110α, P110δ and P110β, respectively. LY294002 hydrochloride also inhibits CK2 with an IC50 of 98 nM. LY294002 hydrochloride can be used for pancreatic cancer research.
